- Localized pain
- Behind the abdomen, on the other side of the spine, is the kidney. If you have pain in your back or midsection, it could be a sign that something is wrong with your kidneys. In addition to back or limb pain, muscle stiffness is another subtle sign to watch out for. Various electrolyte imbalances can occur in kidney disease, such as low calcium levels or high phosphorus levels. As a result, the muscles of the hands and feet may develop aches or pains.